Matsui has had an illustrious career thus far. In 1997, she launched a tour dedicated to raising awareness of breast cancer, and released a four-song CD entitled A Gift of Hope that benefited the Y-Me Breast Cancer Organization. Her music was prominently featured in Say It, Fight It, Cure It, a Lifetime special profiling several courageous women battling breast cancer. “My fans come from all backgrounds and I have been approached by various foundations to join in their efforts. When I hear of a cause that resonates with me that I can dedicate my music to, then I am always willing. It is my way to show gratitude and give back,” states Keiko. In 1999, the pianist performed at "A Golden Moment," a skating concert featuring Olympic figure skaters Kristi Yamaguchi, Tara Lipinski, Ekaterina Gordeeva, and Katarina Witt, which benefited the Susan G. Komen Foundation. 1998 saw the release of her album Full Moon And The Shrine, which was accompanied by the acclaimed PBS-TV special Keiko Matsui: Light Above The Trees.

Keiko Matsui’s CD Deep Blue (2001) topped Billboard’s Contemporary Jazz charts for three consecutive weeks. She is the first Japanese artist to achieve this honor. In 2003 she enjoyed success with her recording The Piano, which featured reinventions of some of her most loved original works. In 2004 the title track of Keiko’s Wildflower was used to support the United Nations World Food Programme’s efforts in Africa. "I decided I wanted to support the WFP after learning about the tremendous problems in Africa and how humanitarian assistance can change people’s lives for the better," shares the activist. Keiko has also collaborated with Asians for Miracle Marrow Matches (A3M) in numerous charity concerts. In addition, proceeds from her 2001 mini-CD, A Gift of Life, went to The National Donor Program and Marrow Foundation in support of A3M. In December 2009, the highly sought-after pianist was asked to put together a Christmas show at the Blue Note club in Tokyo, which was a major success and in November 2010 she made her highly anticipated debut at the Blue Note in NY, which was sold out. In 2011 Keiko recorded with fellow pianist Bob James on a four-hand piano project called Altair & Vega. Keiko’s depth as a composer has also allowed her to contribute music to soundtracks in Japan, the U.S. and Russia. She also released her critically heralded Billboard Top 5 recording The Road… which featured Cameroonian bassist Richard Bona and saxophonists Kirk Whalum and Jackiem Joyner among others. In 2013, Keiko Matsui celebrated the release of her critically lauded album Soul Quest, which is the musical inspiration behind Live in Toyko. The same year she was also an invited guest in Istanbul for International Jazz Day alongside such luminaries as Herbie Hancock, Branford Marsalis, and Terence Blanchard. Journey To The Heart (2016) and Echo (2019), further solidified Keiko’s place as one of the most significant and thrilling pianists in contemporary jazz.

Keiko concludes, “During the past few years, I have witnessed the loss of life and seen people's sadness and it has been really painful, but it has helped to remind me of the precious gift of time and the importance of gratitude for what I have now,” confides Keiko.” “Euphoria is my gift to my fans around the world.”